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SEM images of SFD particles prepared from <t>HPC-UL</t> <t>or</t> <t>HPC-SSL</t> at drug-to-polymer ratios of 20/80 and 40/60, and initial spray solution concentrations of 5% and 10% ( w/v ). The scale bar applies to all images.
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Image Search Results


SEM images of SFD particles prepared from HPC-UL or HPC-SSL at drug-to-polymer ratios of 20/80 and 40/60, and initial spray solution concentrations of 5% and 10% ( w/v ). The scale bar applies to all images.

Journal: International Journal of Pharmaceutics: X

Article Title: Spray-freeze-drying aprepitant with hydroxypropyl cellulose increases nasal bioavailability

doi: 10.1016/j.ijpx.2026.100551

Figure Lengend Snippet: SEM images of SFD particles prepared from HPC-UL or HPC-SSL at drug-to-polymer ratios of 20/80 and 40/60, and initial spray solution concentrations of 5% and 10% ( w/v ). The scale bar applies to all images.

Article Snippet: Hydroxypropyl cellulose (HPC) grades HPC-SSL (viscosity 2.0–2.92.5 mPa·s in 2% aqueous solution at 20 °C) and HPC-UL (viscosity 1.7 mPa·s in 2% aqueous solution at 20 °C) were provided by Nippon Soda Co., Ltd. (Tokyo, Japan).

Techniques: Polymer

In vivo pharmacokinetics in rats after nasal administration of aprepitant SFD formulations (20/80, HPC-UL or HPC-SSL, 10% solid content) compared to film-cast ASD formulations of identical composition. Data are presented as mean ( n = 3); error bars are omitted for clarity.

Journal: International Journal of Pharmaceutics: X

Article Title: Spray-freeze-drying aprepitant with hydroxypropyl cellulose increases nasal bioavailability

doi: 10.1016/j.ijpx.2026.100551

Figure Lengend Snippet: In vivo pharmacokinetics in rats after nasal administration of aprepitant SFD formulations (20/80, HPC-UL or HPC-SSL, 10% solid content) compared to film-cast ASD formulations of identical composition. Data are presented as mean ( n = 3); error bars are omitted for clarity.

Article Snippet: Hydroxypropyl cellulose (HPC) grades HPC-SSL (viscosity 2.0–2.92.5 mPa·s in 2% aqueous solution at 20 °C) and HPC-UL (viscosity 1.7 mPa·s in 2% aqueous solution at 20 °C) were provided by Nippon Soda Co., Ltd. (Tokyo, Japan).

Techniques: In Vivo, Drug discovery

Key pharmacokinetic parameters following nasal administration of SFD formulations (10% solid content) compared to film-cast aprepitant formulations. Significant differences in AUCₗₐₛₜ ( p < 0.05) were observed for HPC-UL SFDs (20/80 and 40/60) compared to film-cast HPC-SSL, whereas comparisons with film-cast HPC-UL were not significant ( p = 0.070 and p = 0.135).

Journal: International Journal of Pharmaceutics: X

Article Title: Spray-freeze-drying aprepitant with hydroxypropyl cellulose increases nasal bioavailability

doi: 10.1016/j.ijpx.2026.100551

Figure Lengend Snippet: Key pharmacokinetic parameters following nasal administration of SFD formulations (10% solid content) compared to film-cast aprepitant formulations. Significant differences in AUCₗₐₛₜ ( p < 0.05) were observed for HPC-UL SFDs (20/80 and 40/60) compared to film-cast HPC-SSL, whereas comparisons with film-cast HPC-UL were not significant ( p = 0.070 and p = 0.135).

Article Snippet: Hydroxypropyl cellulose (HPC) grades HPC-SSL (viscosity 2.0–2.92.5 mPa·s in 2% aqueous solution at 20 °C) and HPC-UL (viscosity 1.7 mPa·s in 2% aqueous solution at 20 °C) were provided by Nippon Soda Co., Ltd. (Tokyo, Japan).

Techniques: